IL1F9 ELISA 试剂盒
Quick Overview for IL1F9 ELISA 试剂盒 (ABIN5564184)
抗原
See all IL1F9 ELISA试剂盒适用
检测方法
实验类型
检测范围
应用范围
样品类型
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最低检测浓度
- 3.9 pg/mL
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Analytical Method
- Quantitative
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特异性
- Detects natural and recombinant human IL-36gamma.
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交叉反应
- 人
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灵敏度
- 3 pg/mL
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产品特性
- IL-36gamma (human) ELISA Kit
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Interleukin 1 Family Member 9 (IL1F9) ELISA Kit
IL1F9 适用: 人 Colorimetric Sandwich ELISA 15.6 pg/mL - 1000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Interleukin 1 Family Member 9 (IL1F9) ELISA KitIL1F9 适用: 小鼠 Colorimetric Sandwich ELISA 7.8 pg/mL - 500 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
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板类型
- Pre-coated
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限制
- 仅限研究用
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储存条件
- 4 °C
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储存方法
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Short Term Storage: +4°C
Long Term Storage: +4°C
12 months after the day of manufacturing. See expiry date on ELISA Kit box.
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- IL1F9 (Interleukin 1 Family Member 9 (IL1F9))
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别名
- IL-36gamma
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背景
- IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) are members of the IL-1 cytokine family that bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines occurs mainly in the lung and skin and can be derived from diverse epithelial cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of pro-inflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells (alphabeta T cells and gammadelta T cells) and keratinocyte proliferation. Induction of IL-36gamma in macrophages upon M. tuberculosis infection and its role in the release of antimicrobial peptides has been proposed. IL-36gamma is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines and plays an important role in asthmatic pulmonary inflammation. IL-36gamma might be a potential biomarker of Inflammatory Bowel Disease and is highly expressed in inflamed skin from psoriasis patients and in Allergic Contact Dermatitis. IL-36gamma serum levels are enhanced and correlate to psoriasis severity and response to treatment with anti-TNF.
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